Amy Schumer went from a hustling stand-up comedian to a major movie star.
“After my dad got MS and we went bankrupt and my mom left him, that period from age 12 to 15 was a really rough time,” Schumer recalled to GQ in a 2015 profile. “And we all suffered from it, my siblings and I.”
As a way to help make ends meet, Schumer started performing comedy sets.
Schumer settled down in 2018, marrying chef Chris Fischer after a few months of dating. They welcomed their son, Gene, the next year.
In 2022, Schumer kickstarted a years-long health journey by undergoing liposuction. She later revealed a battle with Cushing syndrome, a condition where the body has too much cortisol, sharing in December 2025 that she lost 50 pounds as a way to “survive” the disease.
Schumer’s weight loss journey was aided by her use of GLP-1 medications, which she has been open about in recent years.
“Three years ago, I tried Wegovy,” she said. “I was puking, I couldn’t handle it. I don’t know if they’ve changed the formula, whatever. But anyway, I went on this Telehealth meeting with Midi Health, and it was cheap. I wanted to try it myself ‘cause I wanted to recommend it to my friends who are nurses and teachers.”
Schumer added that she later switched to Mounjaro and hormonal medications, which helped.
Keep scrolling to revisit Schumer’s transformation through the years:
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